Wolfram syndrome is a rare genetic disorder that affects multiple organs and systems over time. Most people with Wolfram syndrome have mutations in the WFS1 gene, which encodes wolframin, a protein essential for maintaining endoplasmic reticulum (ER) homeostasis and normal cellular function. When wolframin is impaired, cells experience chronic ER stress and mitochondrial dysfunction. Learn more about Wolfram syndrome on our website at https://www.amylyx.com/ | Amylyx Pharmaceuticals Inc.