How major nuclear protein complexes control specialized gene regulation in cancer and beyond

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

High-throughput platform enables aptamer discovery and kinetic profiling

Cell-surface proteins are critical therapeutic targets and are vital to cellular communication, signaling, and homeostasis.

Targeting epigenetic modifiers and splicing regulators together may offer new acute myeloid leukemia treatment paths

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...
Nature

How viral RNAs escape a host mechanism that controls translation

This is a summary of: Liu. H. et al. Viral RNA blocks circularization to evade host codon usage control. Nature https://doi.org/10.1038/s41586-025-09809-y (2025).
Princeton University

Yibin Kang’s team identifies new path to potential cancer treatments

A team of cancer biologists led by Princeton’s Yibin Kang has resolved a confounding paradox about retinoids and cancer cells ...
eLife

Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.