Obstructive sleep apnea (OSA) is characterized by partial or complete airway obstruction during sleep. Prevalence is about 1.2%. [1] [1] Adenotonsillar hypertrophy and obesity are common risk factors ...

Jacqueline M. McMillan, Elizabeth Aitken and Jayna M. Holroyd-Leduc The appropriate assessment and management of chronic insomnia is crucial. Insomnia affects quality of life and has been shown to be ...

Nonalcoholic fatty liver disease refers to a spectrum of diseases from hepatic steatosis to NASH, a condition where fat accumulation causes inflammation and hepatocyte injury leading to cirrhosis. [1] ...

A 77-year-old woman was referred to a geriatric day hospital with concerns about mobility and falls, pain, constipation, cognition and polypharmacy. Comorbidities included cerebrovascular disease, ...

Background: Fragility fractures are a major health concern for older adults and can result in disability, admission to hospital and long-term care, and reduced quality of life. This Canadian Task ...

Smoking marijuana can increase clearance of some drugs Smoked marijuana increases the clearance of theophylline 40%. 1 Similar findings would be expected for other drugs metabolized by CYP1A2, such as ...

KEY POINTS In 2016, 270 204 people in Canada (excluding Quebec) were admitted to hospital for heart conditions, stroke and vascular cognitive impairment, including 107 391 women and 162 813 men, of ...

Bupropion abuse is a growing public health problem Although bupropion shares some structural and pharmacologic properties with amphetamine, early research suggested the drug did not produce any ...

William K. Silverstein, David N. Juurlink and Jonathan S. Zipursky ...

Background: Cancer surveillance data are essential to help understand where gaps exist and progress is being made in cancer control. We sought to summarize the expected impact of cancer in Canada in ...

BACKGROUND: The appropriate timing of hip fracture surgery remains a matter of debate. We sought to estimate the effect of changes in timing policy and the proportion of deaths attributable to ...

Major hemorrhage is a challenging clinical problem that can occur with traumatic injury, postpartum hemorrhage, major surgery and gastrointestinal bleeding. A massive hemorrhage protocol (MHP) should ...