NFL Week 17 kicks off on Christmas Day with three marquee games. Here are the lines for every Week 17 matchup at DraftKings Sportsbook as of Dec. 26. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

The penultimate week of the 2025 NFL regular season is here. USA TODAY Sports provides the early predictions for Week 17.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

NFL Week 17 betting spreads, lines, point totals for every game on NFL Week 17 schedule, with odds for favorites and underdogs in each NFL matchup.

The Week 17 NFL schedule features a smorgasbord of holiday delights. For starters, there are a trio of matchups between double-digit-win teams (five of whom have already punched their postseason tickets, and all of whom are battling for playoff seeding).

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Big Blue opened as three-point favorites on FanDuel and has since moved an obscene amount, 4.5 points, down to +1.5 by Monday midday. This is a wild number to see, and it only makes sense if there are some inklings that Jaxson Dart won’t play in this matchup.

I guess so, because the Texans head to Los Angeles for a date with the Chargers, while the Baltimore Ravens’ playoff hopes are on the line when they visit Green Bay to face a Packers squad on NBC that’s safely in the NFC playoff field.

One of the hottest teams in the NFL right now, led by their No.1 defense, kicks off the Saturday action. C.J. Stroud and the Houston Texans travel to face the Los Angeles Chargers. Both teams are fighting for AFC positioning, making every possession feel like January football.

Preview the NFL Wild Card Round Philadelphia Eagles vs. San Francisco 49ers game with insights, current betting odds including moneyline, spread,

Vaughn Dalzell previews his favorite bets for the Sunday NFL Week 17 schedule, including Seahawks at Panthers, Jacoby Brissett against the Bengals and more!