Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and ...

Researchers decode repair mechanism during transcription of genetic information. Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the ...

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity (CGI) within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

Scientists used magnetic tweezers to reveal how the RNA molecule ‘NIHCOLE’ repairs cell damage, hindering cancer treatments such as radiotherapy. If you want to defeat an enemy, one strategy you can ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

A research team from the University of California (UC), Irvine, has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. The ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...