To adapt to changing environmental pressures, bacteria have developed various methods that allow them to uptake exogenous DNA and incorporate it into their own genomes. One of these processes is ...

DNA topoisomerase I (Topo1) manages the topological state of DNA. Cleavable complexes, the covalent Topo1–DNA intermediates, become DNA damaged when the catalytic cycles are inhibited by the ...

In terms of efficiency, the phosphoramidite method used for synthesizing DNA oligonucleotides is hard to top. Each base-adding step achieves a 99.5% yield. But the method still can’t produce sequences ...

Combining MAGE with CAGE allowed the genome to manipulated as an editable and evolvable template. Scientists have combined a recently developed technique known as multiplex automated genome ...

Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the potency of the resulting PEI2-GNPs conjugates ...